Oxyphil cells appearrounded by a small amount of cytoplasm.

Regulated dose The drug modifies afinely regulated body function which can be easilymeasured.

The N-terminus is divided in three subdomains: the transactivation domains 1 and 2(TAD1 and TAD2) and the proline-rich domain (PRD); the central domain is the DNA-bindingdomain (DBD); and, the C-terminus is formed by the nuclear localization sequence (NLS), theoligomerization domain (OD) and the regulatory domain (RD) [ 60 ].

Inadequate sedation is unacceptable in avulnerable child that may be unable to move orcommunicate its distress due to the use of musclerelaxants, while the unparalysed child may“?ght” the ventilator, leading to ineffective venti-lation, accidental extubation or the loss of inva-sive access or monitors.

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